Azithromycin is an antibiotic in the macrolide family. Azithromycin is a very common antibiotic that is used to treat many different kinds of infection. Azithromycin is rarely used to treat acne. However, there are some reports that Azithromycin helped improve acne symptoms. Azithromyocin is typically administered orally. People with allergies to Clindamycin, Erythromycin or Pristinamycin should avoid taking Azithromycin due to increased risk of side effects.