Tobramycin

Combination Tobramycin and Dexamethasone Ointment (Nebracin)

Tobramycin (Tobrex) is an antibiotic in the Aminoglycoside family. It is used topically to treat certain kinds of bacterial infections of the skin and eye.

Tobramycin is rarely used as a treatment for acne. Tobramycin has minimal activity against most gram-positive bacteria, a group which includes the acne-causing P. acnes bacterium. Laboratory testing has consistently confirmed that P. acnes bacteria are highly resistant to members of the Aminoglycoside antibiotic family. It is unlikely that Tobramycin will be an effective treatment for most individuals with acne.

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Paromomycin

Paromomycin (Gabbroral) 250mg Tabs

Paromomycin (Gabbroral) is an antibiotic in the Aminoglycoside family. It is used to a limited subset of skin and digestive tract infections.

Paromomycin is available in topical and oral formulations. Topical Paromomycin is rarely used as an acne treatment, and it is only available in some countries. Oral Paromomycin is never used as an acne treatment because this medication is not absorbed into the bloodstream from the digestive tract.

Laboratory testing has demonstrated that the acne-causing P. acnes bacteria is naturally resistant to Aminoglycoside family antibiotics, including Paromomycin. This medication is not widely available and there is little clinical research into the efficacy of Paromomycin as a treatment for acne symptoms.

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Neosporin

Neosporin Ointment

Neosporin is a topical antibiotic ointment that is a combination of three medications – Neomycin, Polymyxin B and Bacitracin. Neopsporin is a very popular Over The Counter (OTC) topical antibacterial treatment for minor skin injuries and infections.

Neosporin is rarely used as an acne treatment. But Neosporin is frequently used to prevent infection and accelerate healing after draining an acne lesion (popping/lancing a pimple).

Neosporin does not appear to be an effective treatment for active acne symptoms. There is very few clinical research or patient reports that suggest Neosporin is an effective treatment for acne. This ineffectiveness may be because the acne-causing P. acnes bacterium has some level of natural resistance to each of the antibiotics included in Neosporin.

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Neomycin

Neomycin Ointment

Neomycin is an antibiotic in the Aminoglycoside family. It is primarily available as a topical ointment and is used to treat certain types of skin infections. Neomycin is often combined with other antibiotics into combination topical ointments (eg. Neosporin) that are used in first aid skin care.

Topical Neomycin ointment is rarely used as a treatment for acne. Many gram-positive bacteria, including the acne-causing P. acnes bacterium, are naturally resistant to Neomycin and other Aminoglycoside family antibiotics. There is limited clinical research into the effectiveness of topical Neomycin as a treatment for active acne.

Neomycin-containing topical ointments, such as Neosporin, are most commonly used to prevent infection and accelerate healing after draining an acne lesion (popping/lancing a pimple).

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Gentamicin

Gentamicin (Garamycin) Topical Cream

Gentamicin (Garamycin) is an antibiotic in the Aminoglycoside family. Topical Gentamicin is used to treat certain skin infections that are caused by gram-negative bacteria.

Topical Gentamicin is rarely used as an acne treatment. This is largely due to the fact that the acne-causing P. acnes bacterium is naturally resistant to most Aminoglycoside antibiotics, including Gentamicin.

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