Thiamphenicol (Biothicol) is an antibiotic in the Amphenicol family. It is primarily used to treat certain types of urinary tract and sexually transmitted bacterial infections.
Thiamphenicol is rarely used for the treatment of acne. Thiamphenicol is not approved for human use in all countries, but it is widely used in other countries.
Laboratory testing indicates that acne-causing Propionibacterium acnes bacteria are moderately susceptible to Thiamphenicol, as well as it’s closely-related cousin Chloramphenicol. High-level antibiotic resistance to to Thiamphenicol among P. acnes bacteria is rare. There is also a small amount of clinical research that suggests Thiamphenicol can be an effective treatment for individuals with moderate to severe acne.
Additional research and patient reports are needed to determine the best role (if any) of Thiamphenicol in acne treatment regimens.
Chloramphenicol (Clorin) is an antibiotic that is used to treat a wide range of bacterial infections. Chloramphenicol is used as a topical treatment for bacterial conjunctivitis (eye infections).
Chloramphenicol is generally used as a topical treatment for acne. Oral Chloramphenicol is rarely used to treat acne. Laboratory research suggests that the acne causing P. acnes bacteria is moderately susceptible to chloramphenicol. User reports suggest that topical chloramphenicol may be a useful acne treatment.
Oral formulations of chloramphenicol are not approved for human use in many countries, and are no longer widely available.