Telithromycin

Telithromycin (Ketek) Tablets

Telithromycin (Ketek) is an antibiotic in the Macrolide family. It is primarily used to treat certain types of bacterial respiratory infections.

Telithromycin is rarely used as a treatment for acne symptoms. There have been some safety concerns about the effect that this antibiotic has on the liver. The use of this medication in the United States was curtailed in 2007, and it is not widely used and may not be available in all countries.

Telithromycin may be useful in the treatment of acne, but there is little clinical research about this application. Laboratory testing indicates that acne-causing Propionibacterium acnes bacteria tend to be susceptible to Macrolide family antibiotics, which includes Telithromycin. At least one study has reported that Telithromycin is substantially more toxic to P. acnes bacteria than other Macrolides that are commonly used for the treatment of acne (eg. Erythromycin, Azithromycin).

P. acnes bacteria that are resistant to Macrolide family antibiotics are becoming increasingly common in many places around the world. However, many of these antibiotic-resistant P. acnes bacteria may still be susceptible to Telithromycin because of its unique molecular features.

Telithromycin is an antibiotic that warrants further study into its utility as a treatment of acne vulgaris.

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Spiramycin

Spiramycin Tablets

Spiramycin (Spirex) is an antibiotic in the Macrolide family. It has both antibacterial and antiparasitic properties. Spiramycin is used to treat a limited range of infections, and this medication is not available in all countries.

Spiramycin is rarely used as a treatment for acne. There is minimal clinical research into the efficacy of Spiramycin as an acne treatment. Other members of the Macrolide family (eg. Erythromycin, Azithromycin, etc) are more widely available and commonly used. Laboratory testing indicates that the acne-causing P. acnes bacteria is less susceptible to Spiramycin than to other Macrolide family antibiotics.

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Roxithromycin

Roxithromycin (Cyrox) Tablets

Roxithromycin (Roxicin) is an antibiotic in the Macrolide family. It is used to treat certain types of respiratory, urinary and soft tissue infections that are caused by susceptible bacteria.

Roxithromycin is occasionally used to treat acne. Clinical research has indicated that Roxithromycin (and other Macrolide family antibiotics) can be effective acne treatments. Roxithromycin may be particularly helpful for the treatment of acne because this antibiotic can accumulate inside of certain types of white blood cells. This accumulation may help the immune system better control the growth of the acne-causing P. acnes bacterium. This accumulation may also help limit the inflammation that causes acne symptoms such as pimples, nodules, cysts and scars.

Laboratory testing has demonstrated that Macrolide family antibiotics, including Roxithromycin, are active against P. acnes bacteria. However, P. acnes bacteria that are highly resistant to Macrolide family antibiotics are becoming increasingly common in many places in the world. Patients with acne infections caused by these resistant bacteria are less likely to see a benefit from antibiotic therapy with Roxithromycin, and other Macrolides.

Roxithromycin is not available in all countries (eg. United States).

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Pristinamycin

Pristinamycin (Pyostacine) 500mg Tablets and Packaging

Pristinamycin (Pyostacine) is an antibiotic that is used to treat certain types of infections caused by gram-positive bacteria (eg. Staph infections). Pristinamycin is a natural combination of two complementary antibiotics – Pristinamycin IA an Pristinamycin IIA. Pristinamycin IA is a cyclic hexadepsipeptide antibiotic, and Pristinamycin IIA is in the Macrolide family of antibiotics.

Pristinamycin is rarely used as an acne treatment, but laboratory testing indicates that the acne-causing P. acnes bacterium is susceptible to Pristinamycin. Pristinamycin is occasionally used to treat non-acne infections that are caused by P. acnes bacteria.

Pristinamycin is only available in a few countries. But in countries where it is available, Pristinamycin is an antibiotic that warrants further investigation as an acne treatment.

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Josamycin

Josamycin (Josaxin) 500mg Tablets

Josamycin (Josaxin) is an antibiotic in the Macrolide family. It is used to treat certain types of bacterial infection, particularly those caused by anaerobic bacteria.

Josamycin is occasionally used as an acne treatment. Laboratory testing indicates that the acne-causing P. acnes is moderately susceptible to this antibiotic. Additionally, Josamycin may retain antibacterial activity against some P. acnes bacteria that are resistant to other Macrolide antibiotics (eg. Erythromycin).

Josamycin has a moderately short half-life and is often taken multiple times a day. This drug is not recommended for people with liver problems.

Josamycin is not approved for human use in all countries.

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Dirithromycin

Dirithromycin (Dynabac) 250mg Tablets

Dirithromycin (Dynabac) is an antibiotic in the Macrolide family. Dirithromycin is rarely used for the treatment of acne. There is little evidence on the efficacy of dirithromycin as an acne treatment. This medication is not currently available in all countries (eg. United States).

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Clarithromycin

Clarithromycin 500mg Tablets

Clarithromycin (Biomycin) is an antibiotic in the Macrolide family. Clarithromycin has a broad spectrum activity of activity against many types of bacteria, including those that cause strep throat, pneumonia, skin infections and stomach ulcers.

Clarithromycin is ocassionally used for the treatment of acne symptoms. Topical Clarithromycin is occasionally prescribed as an acne treatment. Oral Clarithromycin is rarely used to treat acne. Other antibiotics in the Macrolide family (eg. Azithromycin, Erythromycin) are more commonly used as acne treatments.

Antibiotic susceptibility testing indicates that Clarithromycin tends to be active against the acne-causing P. acnes bacterium. However, P. acnes bacteria that are highly resistant to Clarithromycin (and other Macrolide family antibiotics) are becoming increasingly common in many regions. Clinical research and patient reports suggest that Clarithromycin (particularly topical Clarithromycin) can significantly improve acne symptoms for some patients. Topical Clarithromycin is often combined with a complementary treatments.

Clarithromycin is widely available as a generic, although this medication can be quite expensive in certain countries (eg. United States).

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Erythromycin

Erythromycin (Aknemycin) 2% Topical Ointment

Erythromycin is an antibiotic in the Macrolide Family. It is a widely used antibiotic that can be applied topically or ingested orally. Erythromycin is used to treat many types of bacterial infections, including those of the respiratory tract, urinary tract and skin.

Erythromycin is commonly used for the treatment of acne symptoms. Topical erythromycin is a popular choice for treating mild to moderate acne symptoms (Acne Types: 1-3). Oral Erythromycin is occasionally used as an acne treatment, but other Macrolide family antibiotics are often preferred for oral use because they tend to have fewer side effects.

An abundant number of clinical research and patient reports that show Erythromycin can be an effective treatment for many individuals with acne. Antibiotic susceptibility testing indicates that the acne-causing P. acnes bacterium is generally sensitive to Macrolide family antibiotics, including Erythromycin. However, P. acnes bacteria that are resistant to Erythromycin and other Macrolide antibiotics are becoming common in many regions of the world. Individuals with acne symptoms caused by these resistant bacteria are not likely to benefit from treatment with Erythromycin.

Erythromycin is often combined with benzoyl peroxide in topical formulations (eg. Benzamycin). Topical Erythromcyin is often combined with complementary treatments (eg. Oral Antibiotics, Retinoids, Hormonal Treatments, etc) as part of a comprehensive acne treatment plan.

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Azithromycin

Azithromycin 100mg Capsules

Azithromycin is an antibiotic in the Macrolide Family. Azithromycin is a very common antibiotic that is used to treat many different kinds of infections.

Azithromycin is rarely used to treat acne. However, there are some reports that Azithromycin helped improve acne symptoms.  Antibiotic susceptibility testing indicates that the acne-causing P. acnes bacterium tends to be susceptible to antibiotics in the Macrolide family, including Azithromycin. However, Macrolide-resistant P. acnes bacteria are becoming common in many regions of the world.

Azithromycin is primarily used as an oral antibiotic, but topical Azithromycin is available in some regions. Individuals with allergies to Clindamycin, Erythromycin or Pristinamycin should avoid taking Azithromycin due to increased risk of side effects.

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