Penicillin V

Penicillin V Potassium 500mg Tablets

Penicillin V (Phenoxymethylpenicillin) is an antibiotic in the Penicillin family. Penicillin V is used to treat many different types of bacterial infections. This antibiotic is primarily active against gram-positive bacteria, which includes the acne-causing Propionibacterium acnes bacterium.

Penicillin V is available in topical and oral formulations. Penicillin V is occasionally used as an oral antibiotic for the treatment of acne. For topical use, the closely-related Penicillin G is more commonly prescribed.

Penicillin V and Penicillin G are notable because they consistently score very well in laboratory testing of antibiotic susceptibility of the P. acnes bacterium. These antibiotics kill P. acnes bacteria at very low concentrations, and Penicillin-resistant P. acnes bacteria are very uncommon.

Clinical research and patient reports have indicated that oral treatment with Penicillin family antibiotics (eg. Amoxicillin, Ampicillin, Penicillin V) is effective at improving acne symptoms for many patients. The topical use of Penicillin also appears to be a useful acne treatment.

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Penicillin G

Penicillin Ointment

Penicillin G (Benzylpenicillin) is an antibiotic in the Penicillin family. Penicillin G is used to treat a wide range of bacterial infections. This antibiotic is primarily active against gram-positive bacteria, which includes the acne-causing P. acnes bacterium.

Penicillin G is occasionally used in the treatment of acne, usually as a topical treatment. For oral antibiotic treatment, Penicillin V (which is closely related to Penicillin G) is much more popular than Penicillin G because it is more stable in the digestive tract.

Penicillin G and Penicillin V are notable because they consistently score very well in laboratory testing of antibiotic susceptibility of the P. acnes bacterium. These antibiotics kill P. acnes bacteria at very low concentrations, and Penicillin-resistant P. acnes bacteria are very uncommon. Clinical research and patient reports have indicated that oral treatment with Penicillin family antibiotics (eg. Amoxicillin, Ampicillin, Penicillin V) is effective at improving acne symptoms for many patients.

Topical Penicillin G appears to be a useful treatment for acne. Creams and ointments that contain Penicillin G are available Over The Counter (OTC) in many countries. Penicillin-containing ointments are especially popular in Central and South America. Several of these ointments combine Penicillin G with a complementary antibiotic from a different antibiotic family (eg. Sulfonamide).

Clinical research on the use of these Penicillin G combination ointments for acne treatment is currently limited. But patient reports and laboratory antibiotic susceptibility testing both suggest that some of these combination ointments (eg. Penicillin plus Sulfathiazole) may be uniquely effective acne treatments. More research is needed, but this subset of topical antibiotic treatments clearly warrants greater interest from the acne community.

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Flucloxacillin

Flucloxacillin (Halopen) Capsules

Flucloxacillin (Floxapen) is an antibiotic in the Penicillin family. Flucloxacillin is a narrow-spectrum antibiotic that is used to treat a subset of respiratory, skin and other bacterial infections.

Flucloxacillin is rarely used to treat acne. Laboratory research indicates that the acne-causing P. acnes bacterium is susceptible to Penicillin family antibiotics, including Flucloxacillin. But there is little clinical research into the efficacy of Flucloxacillin as a treatment for acne.

This antibiotic is not currently available in all countries.

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Dicloxacillin

Dicloxacillin Capsules and Blisterpack

Dicloxacillin (Diclocil) an antibiotic in the Penicillin family. Dicloxacillin is a narrow spectrum antibiotic that is used primarily against Gram-positive bacteria that produce an enzyme called beta lactamase. Dicloxacillin is used to treat a variety of skin infections that are caused by Staphylococcus bacteria.

Dicloxacillin is rarely used to treat acne. For the treatment of acne, other Penicillin family antibiotics (eg. Amoxicillin, Ampicillin) are more common. Laboratory research indicates that the acne-causing P. acnes bacterium is very sensitive to Penicillins, including Dicloxacillin. Therefore, this medication may have some utility as an acne treatment. Dicloxacillin is widely available in combination with Amoxicillin or Ampicillin.

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Cloxacillin

Cloxacillin 500mg Capsules

Cloxacillin (Cloxapen) is an antibiotic in the Penicillin family. It is used to treat several types of bacterial infections.

Cloxacillin is rarely used for the treatment of acne symptoms. However, laboratory research indicates that the acne-causing P. acnes bacteria is highly sensitive to Penicillin family antibiotics, such as Cloxacillin. There is little clinical research and few patient reports about the efficacy of Cloxacillin as an acne treatment.

Cloxacillin is available as a single agent and in combination with amoxicillin or ampicillin. People with a history of allergic reactions to Penicillin family antibiotics (eg. Amoxicillin, Ampicillin) have an increased risk of side effects when using Cloxacillin.

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Augmentin

Amoxicillin plus Clavulanic Acid (Augmentin) Tablets

Augmentin is an combination antibiotic that combines Amoxicillin and Clavulanic Acid. Amoxicillin is an antibiotic in the Penicillin family. Clavulanic Acid prevents bacteria from inactivating Amoxicillin by blocking the activity of a bacterial enzyme called beta-lactamase.

Augmentin is not a common acne treatment, but there is some evidence to suggest that Augmentin can effective for individuals with acne. The acne-causing P. acnes bacterium tends to be very sensitive to Penicillin family antibiotics. Augmentin is expected to be at least as effective than Amoxicillin alone, but Augmentin tends to be substantially more expensive.

Individuals who are allergic to Amoxicillin, Ampicillin or Penicillin have an increased risk of side effects from Augmentin treatment.

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Ampicillin

Ampicillin (Ampisyn) 250mg Capsules

Ampicillin is an antibiotic in the Penicillin Family. Ampicillin is a very common antibiotic that is used to treat many different kinds of infection.

Ampicillin is rarely used to treat acne. There is limited evidence about the efficacy of Ampicillin for treating acne symptoms. Antibiotic susceptibility testing indicates that the acne-causing P. acnes bacterium tends to be highly sensitive to antibiotics in the Penicillin family, including Ampicillin.

Ampicillin should not be used by people that are allergic to Penicillin family antibiotics (eg. Penicillin V, Amoxicillin) due to an increased risk of side effects.

Amoxicillin

Amoxicillin Capsules

Amoxicillin an antibiotic in the Penicillin family. Amoxicillin is a very common antibiotic that is used to treat many different kinds of infection.

Amoxicillin is occasionally used to treat acne. Many acne patients have reported that Amoxicillin helped improve their acne symptoms. Antibiotic susceptibility testing indicates that the acne-causing P. acnes bacterium tends to be highly sensitive to antibiotics in the Penicillin family, including Amoxicillin.

Amoxicillin should not be used by people that are allergic to Penicillin family antibiotics (eg. Penicillin G, Ampicillin) due to an increased risk of side effects.

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