Sparfloxacin

Sparfloxacin (Zospar) 100mg Tablets

Sparfloxacin (Zospar) is an antibiotic in the Quinolone family. It is used to treat certain types of bacterial infections of the respiratory tract, urinary tract and skin.

Sparfloxacin is rarely used as a treatment for acne. There is minimal clinical research into the efficacy of Sparfloxacin as a treatment for active acne symptoms. However, laboratory testing does suggest that Sparfloxacin has certain properties that could make it a uniquely effective acne treatment.

Antibiotic susceptibility testing indicates that the acne-causing P. acnes bacterium is highly sensitive to Sparfloxacin. In addition, Sparfloxacin is absorbed by certain types of white blood cells, which may help the immune system better control the growth of acne-causing bacteria. Lastly, Sparfloxacin has been shown to accumulate in the skin following oral administration.

More research is needed on the utility of Sparfloxacin for the treatment of acne, but it is an antibiotic that deserves further investigation.

Sparfloxacin is only available in oral formulations and this medication is not available in all countries (eg. United States).

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Ofloxacin

Ofloxacin (Surgiflox) 200mg Tablets

Ofloxacin (Floxin) is an antibiotic in the Quinolone family. Ofloxacin is a mixture of two closely related molecules, Levofloxacin and Dextrofloxacin. Levofloxacin provides the majority of the antibacterial activity of Oflaxcin. The use of Oflaxcin has declined in recent years as a pure Levofloxacin (Levaquin) has become more widely available.

Ofloxacin is rarely used to treat active acne. There is little clinical research about the efficacy of Ofloxacin as a treatment for acne. However, laboratory antibiotic susceptibility testing indicates that the acne-causing P. acnes bacterium is generally sensitive to Quinolone family antibiotics, including Ofloxacin.

Ofloxacin is available in oral and topical formulations. For the treatment of acne, other Quinolone family antibiotics (eg. Levofloxacin, Moxifloxacin, Ciprofloxacin) are generally preferred over Ofloxacin.

Topical Ofloxacin may be useful as an acne treatment. But laboratory ad clinical research suggest that other topically-applied Quinolones (eg. Nadifloxacin) may be better suited for use in treating acne.

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Norfloxacin

Norfloxacin 400mg Tablets

Norfloxacin (Norflox) is an antibiotic in the Quinolone family. It is a broad spectrum antibiotic that is used to treat certain types of respiratory, urinary tract and sexually transmitted bacterial infections.

Norfloxacin is rarely used as an acne treatment, and there is little clinical research into the effectiveness of Norfloxacin for improving acne symptoms. Other Quinolone family antibiotics (eg. Ciprofloxacin, Nadifloxacin) are more commonly used in acne treatments.

Laboratory antibiotic susceptibility testing has indicated that more strains of P. acnes bacteria are resistant to Norfloxacin, than other comparable Quinolone antibiotics. When a strain of P. acnes is susceptible to Norfloxacin, sensitivity to this antibiotic tends to be similar to that of Ciprofloxacin.

Norfloxacin has been reported to have a higher rate of adverse events compared to other members of the Quinolone antibiotic family. Because of this, and the fact that there is little evidence that Norfloxacin is significantly better than alternative antibiotics, the use of Norfloxacin is fairly limited in many regions.

Norfloxacin is generally used as an oral antibiotic, but topical formulations are available in some regions.

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Nalidixic Acid

Nalidixic Acid (Wintomylon) Tablets

Nalidixic Acid (Wintomylon) is an antibiotic in the Quinolone family. It is primarily used to treat certain infections caused by gram-negative bacteria.

Nalidixic Acid is rarely used as an acne treatment. Nalidixic Acid has weak antibacterial against most gram-positive bacteria, which includes the acne-causing P. acnes bacterium. Laboratory testing indicates that many strains of P. acnes bacteria are highly resistant to Nalidixic Acid. There is little clinical research and few patient reports about the efficacy of Nalidixic Acid as a treatment for acne.

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Moxifloxacin

Moxifloxacin (Mofoxin) Tablets

Moxifloxacin (Avelox) is a broad-spectrum antibiotic in the Quinolone family. Moxifloxacin is used to treat a variety of bacterial infections. It is widely available in oral and topical (opthalmic) formulations.

Moxifloxacin is rarely used as a treatment for acne. But there is some evidence to suggest that Moxifloxacin can be a useful acne treatment. Laboratory testing indicates that the acne-causing P. acnes bacterium is moderately more susceptible to Moxifloxacin than Ciprofloxacin, which is a more commonly used antibiotic in the Quinolone family.

The clinical research into the effectiveness of Moxifloxacin at reducing acne symptoms is limited. Additional research and patient surveys will be required to determine whether Moxifloxacin should be more commonly considered for acne treatment regimens.

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Levofloxacin

Levofloxacin (Levoflox) 750mg Tablets

Levofloxacin (Levoflox) is an antibiotic in the Quinolone family. It is used to treat a range of bacterial infections, including respiratory, eye and urinary tract infections.

Levofloxacin is rarely used as an acne treatment. However, laboratory testing indicates that the acne-causing P. acnes bacterium is generally susceptible to this antibiotic. Several studies have indicated that oral Levofloxacin may be more effective at controlling acne symptoms than other members of the Quinolone antibiotic family (eg. Ciprofloxacin).

Levofloxacin is available in oral and topical formulations. Oral Levofloxacin is a more commonly used as an acne treatment than topical Levofloxacin. Topical Levofloxacin is generally available as an opthalmic ointment, but these medications can be applied directly to the skin.

Levofloxacin (and other Quinolones) are not recommended for use in pregnant women and growing children because these medications can cause musculoskeletal side effects in people with growing bones and teeth. Quinolones also tend to have moderately higher rates of adverse events than many other forms of oral antibiotics.

The cost of Levofloxacin is low in many countries, but it can be very expensive in certain places where the supply is more tightly controlled (eg. United States).

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Gemifloxacin

Gemifloxacin (Toplon) Tablets

Gemifloxacin (G-Cin) is a broad spectrum antibiotic in the Quinolone family. Gemifloxacin is used to treat certain types of bacterial respiratory infections.

Gemifloxacin is rarely used as an acne treatment, and there is minimal evidence regarding its efficacy for this purpose. Laboratory research indicates that the acne-causing P. acnes bacteria is moderately susceptible to Quinolone family antibiotics, including Gemifloxacin.

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Gatifloxacin

Gatifloxacin (Floxagat) Tablets

Gatifloxacin (Tequin) is an antibiotic in the Quinolone family. Gatifloxacin is used to treat certain types of respiratory and eye infections.

Gatifloxacin is rarely used as a treatment for acne and there is limited evidence regarding its efficacy as an acne treatment. Other Quinolone family antibiotics are more commonly used in acne treatment regimens. Gatifloxacin is available in oral and topical formulations. The topical formulations are generally designed for opthalmic use, but Gatifloxacin ointments could be applied directly to the skin.

Gatifloxacin is associated with more frequent severe side effects than many other comparable antibiotics. Because of the elevated risk of side effects, Gatifloxacin is no longer available in many countries.

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Finafloxacin

Finafloxacin Molecule

Finafloxacin (Xtoro) is an antibiotic in the Quinolone family. It was recently approved for use in the United States for the treatment of bacterial ear infections. Finafloxacin is not currently used for the treatment of acne, but the acne-causing P. acnes bacterium is likely to be sensitive to this antibiotic. For treating acne, other members of the Quinolone family (eg. Nadifloxacin, Ciproflocaxin) are more commonly used.

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Nadifloxacin

Nadifloxacin (Nadixa) Topical Antibiotic

Nadifloxacin (Nadixa) is a topical antibiotic in the Quinolone family. Nadifloxacin is used to treat certain types of bacterial skin infections.

Nadifloxacin is occassionally used for the treatment of acne. Clinical research and patient reports suggest that Nadifloxacin can be a very useful acne treatment, particularly when combined with complementary therapies. Laboratory antibiotic susceptibility testing indicates that the acne-causing P. acnes bacterium tends to be sensitive to Nadifloxacin.

Nadifloxacin is not approved for use in all countries (eg. United States). But Nadifloxacin is an exciting new topical treatment for acne that is likely to become more commonly used for acne patients.

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