Sulfathiazole

Sulfatiazol Ointment

Sulfathiazole (Sulfatiazol) is an antibiotic in the Sulfonamide family. It is used as a topical antibacterial to prevent and treat bacterial infections of the skin.

Sulfathiazole is occasionally used as a topical treatment for acne. This medication is often combined with other antibiotics (eg. Penicillin, Trimethoprim) in topical antibacterial ointments.

There is limited clinical or laboratory research into the effectiveness of Sulfathiazole for the treatment of acne symptoms. However, laboratory testing does indicate that the acne-causing P. acnes bacterium tends to moderately susceptible to antibiotics in the Sulfonamide family, such as Sulfathiazole.

Topical ointments that combine Sulfathiazole with a complementary antibiotic (eg. Penicillin G) are more likely to be effective at improving acne symptoms than Sulfathiazole alone. Topical Sulfathiazole may better control acne symptoms when be combined with complementary therapies.

A very old medical report (1951) suggested that direct injection of a Sulfathiazole solution into inflammatory acne cysts was an effective treatment, but this approach has not been widely practiced. Other members of the Sulfonamide family (eg. Dapsone, Silver Sulfadiazine, Sulfacetamide) are more commonly used as topical treatments for acne.

Sulfathiazole Images

Sulfamethoxazole

Combination Sulfamethoxazole and Trimethoprim (Bactropin) Tablets

Sulfamethoxazole (SMX) is an antibiotic in the Sulfonamide family. It is used to treat certain types of respiratory tract, urinary tract and skin infections that are caused by bacteria. Sulfamethoxazole is rarely used alone. It is primarily available in combination with another antibiotic called Trimethoprim. This combination is called Co-Trimoxazole, and it is a very common antibiotic.

Sulfamethoxazole is rarely used by itself as a treatment for acne. However, Co-Trimoxazole is a popular treatment for moderate to severe acne symptoms. Both clinical research and laboratory testing indicates that Co-Trimoxazole can be an excellent acne treatment, particularly for individuals with inflammatory acne symptoms.

Laboratory testing has indicated that the acne-causing P. acnes bacteria is moderately susceptible to Sulfamethoxazole. P. acnes bacteria are also moderately susceptible to Trimethoprim. These two antibiotics are synergistic, and the combination is substantially more toxic to P. acnes bacteria.

Sulfamethoxazole Images

Sulfafurazole

Sulfisoxazole Molecule

Sulfafurazole (Sulfisoxazole) is an antibiotic in the Sulfonamide family. It is a short-lived antibiotic that is active against certain types of gram-positive and gram-negative bacteria. This medication is not available in all countries and it is not a commonly used medication.

Sulfisoxazole is rarely used to treat acne. For the treatment of active acne symptoms, other Sulfonamide family antibiotic (eg. Sulfamethoxazole, Dapsone, Silver Sulfadiazine) are much more commonly used.

Sulfisoxazole may be available in oral and topical formulations.

Sulfisoxazole Images

Sulfadoxine

Combination Sulfadioxine and Pyrimethamine (Sulphadar) Tablets

Sulfadoxine (Sulphadoxine) is an antibiotic in the Sulfonamide family. It is primarily used in combination with Pyrimethamine for the treatment of malaria.

Sulfadoxine is rarely used as a treatment for acne. There is minimal clinical research or laboratory testing on the utility of Sulfadoxine as an acne treatment. Laboratory testing indicates that the acne-causing P. acnes bacterium is tends to be moderately sensitive to Sulfonamide family antibiotics, such as Sulfadoxine.

For the treatment of active acne symptoms, other Sulfonamide family antibiotics (eg. Sulfamethoxazole, Dapsone. Sulfadiazine) are more commonly prescribed.

Sulfadoxine Images

Sulfadimethoxine

Sulfadimethoxine (Albon) 250mg Tablets

Sulfadimethoxine (Albon) is an antibiotic in the Sulfonamide family. It is primarily used in veterinary medicine, but it is approved for human use in several countries (eg. Russia).

Sulfadimethoxine is rarely used as an acne treatment. For the treatment of active acne symptoms, other oral Sulfonamide antibiotics (eg. Sulfamethoxazole) are far more commonly prescribed. Sulfadimethoxazole is primarily available in oral formulations.

Clinical research on this medication as an acne treatment is limited,. But the research that does exist indicates that Sulfadimethoxine is a partially effective treatment for patients with moderate to severe acne vulgaris. However, this research also found that Tetracycline and Erythromycin were substantially more effective than Sulfadimethoxine.

Sulfadimethoxine Images

Sulfacetamide

Sodium Sulfacetamide Lotion

Sulfacetamide is a topical antibiotic in the Sulfonamide family. It is used to topically to treat certain types of skin infections, including acne. Sulfacetamide is available in topical formulation by itself or in combination with Sulfur.

Sulfacetamide is commonly used to treat acne symptoms and it is marketed directly for this purpose. Research and patient reports indicate that Sulfacetamide is effective for some patients, particularly those with mild to moderate acne symptoms. Laboratory antibiotic susceptibility testing indicates that that the acne-causing P. acnes bacterium tends to be moderately susceptible to Sulfonamide family antibiotics, such as Sulfacetamide.

Topical Sulfacetamide is generally well-tolerated by patients with minimal side effects. Sulfacetamide is often combined with complementary therapies as part of a comprehensive acne treatment plan.

Sulfacetamide Images

Silver Sulfadiazine

Silver Sulfadiazine (Ascend) Ointment

Silver Sulfadiazine (Silvadene) is an antibiotic in the Sulfonamide family. Silver Sulfadiazine also contains ionic silver, which has antibacterial properties. Silver Sulfadiazine is used to treat certain types of bacterial skin infections, and is commonly used to prevent secondary infections in burn patients.

Silver Sulfadiazine is occasionally used as a topical treatment for acne. Although there is minimal clinical research on the efficacy of Silver Sulfadiazine for the treatment of acne, some patients have reported that this medication helped improve their acne symptoms.

Antibiotic susceptibility testing indicates that the acne-causing P. acnes bacterium tends to be moderately susceptible to Sulfonamide antibiotics, including Sulfadiazine. Silver Sulfadiazine is likely to be most effective when combined with complementary systemic or topical acne treatments. Silver Sulfadiazine is a medication that deserves further investigation into its utility as an acne treatment.

Silver Sulfadiazine Images

Mafenide

Mafenide (Sulfamylon) Packaging

Mafenide is an antibiotic in the Sulfonamide family. Mafenide is a topical antibiotic that is used to treat certain kinds of skin infections. It is commonly used to treat burn injuries and prevent secondary infections.

Mafenide is rarely used as an acne treatment. However, there have been some patient reports that suggest that Mafenide can be a useful treatment for people with mild to moderate acne symptoms. Laboratory testing indicates that the acne-causing P. acnes bacterium tends to be moderately sensitive to Sulfonamide family antibiotics, such as Mafenide.

Topical Mafenide may be most effective when combined with a complementary treatment as part of a comprehensive acne treatment plan.

Mafenide Images

Dapsone

Dapsone (Aczone) Gel

Dapsone is an antibiotic in the Sulfonamide family. It is used to treat a range of infections, including Leprosy, respiratory and skin infections.

Dapsone was once a popular choice for treating moderate to severe acne in the mid 20th century, but its use declined when oral Isotretinoin (Accutane) was introduced. However, Dapsone is now regaining popularity as an acne treatment.

Antibiotic susceptibility testing indicates that the acne-causing P. acnes bacterium tends to be moderately susceptible to Dapsone. A wealth of clinical research demonstrates that oral Dapsone can be an effective treatment for individuals with inflammatory acne. Patients have also reported positive results from the use of topical Dapsone gel.

Dapsone is widely available in oral and topical formulations. Topical Dapsone is a relatively new formulation that is specifically marketed as an acne treatment. Cotrimoxazole (also in the Sulfonamide antibiotic family) is more commonly used oral antibiotic than Dapsone, but it is unclear which of these medications is a more effective acne treatment.

People with a history of allergic responses to Sulfonamide (Sulfa) drugs have an elevated risk of adverse events when using Dapsone.

Dapsone Images

Cotrimoxazole

Co-Trimoxazole (Septra) Tablets

Cotrimoxazole is a combination of two antibiotics – Trimethoprim and Sulfamethoxazole. Cotrimoxazole is used to treat many kinds of bacterial infections, such as urinary tract, respiratory and skin infections.

Sulfamethoxazole is a member of the Sulfonamide family. Sulfamethoxazole and Trimethoprim work together to prevent bacteria from synthesizing folic acid, an essential B vitamin.

Cotrimoxazole is occasionally used to treat acne. Clinical research and patient reports suggest that cotrimoxazole can be a very effective treatment for some people with moderate to severe inflammatory acne (Acne Types:2-4). Clotrimoxazole is often effective for individuals who have not benefited from common anti-acne antibiotics (eg. Minocycline, Doxycycline, Clindamycin). Antibiotic susceptibility testing indicates that the acne-causing P. acnes bacteria tends to be moderately susceptible to Sulfamethoxazole and Trimethoprim, individually. The combination (Cotrimoxazole) is substantially more toxic to P. acnes bacteria.

There is a greater risk of significant side effects and allergic reactions when using Cotrimoxazole than many of the other oral antibiotics used to treat acne. In particular, Cotrimoxazole has been associated with an auto-immune reaction called Stevens–Johnson syndrome, which can be life-threatening. Although the risk is small, this may explain why Cotrimoxazole is not more widely used for the treatment of acne. Individuals with a history of allergic reactions to Sulfonamide antibiotics should avoid using Cotrimoxazole.

Cotrimoxazole Images