RU58841

RU58841 Solution (Anageninc)

RU58841 is an Androgen Inhibitor medication. This medication is used topically, primarily for the treatment of androgenic alopecia (androgen-induced balding). RU58841 was developed as topical a treatment for hair-loss, hirsuitism and acne. Although this medication was never commercialized, it is occasionally used to treat hair loss and is widely available online. RU58841 is not generally used as a treatment for acne.

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Cimetidine

Cimetidine Tablets

Cimetidine (Tagamet) is a medication that is used primarily to treat heartburn and peptic ulcers, but also functions as a weak Androgen Inhibitor. Cimetidine is a histamine H2 receptor antagonist that was once among the most commonly used medications to treat heartburn, but has since been largely replaced by newer medications with fewer side effects. Cimetidine is rarely used as a treatment for acne.

Cimetidine has been shown to be a weak Androgen Inhibitor in several research studies. Cimetidine can block the activity of the androgen hormones testosterone and dihydrotestosterone (DHT), particularly at higher dosages. Cimetidine has also been shown to increase levels of the female hormone estrogen. Cimetidine was tested as both an oral and topical treatment for acne in several clinical research studies. Treatment with Cimetidine was found to improve acne symptoms a little bit in some patients, but Cimetidine was generally less effective for treating acne than other Androgen Inhibitors (eg. Spironolactone).

Androgen hormones stimulate the growth and activity of the sebaceous glands and production of sebum. Excessive sebaceous gland activity can contribute to acne symptoms. Androgen Inhibitors such as Cimetidine may help improve acne symptoms by reducing the effects of elevated androgen levels.

Oral formulations of Cimetidine are available as Over-The-Counter (OTC) medications for the treatment of heartburn.

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Fluridil

Fluridil (Eucapil)

Fluridil (Topilutamide, Eucapil) is an Androgen Inhibitor medication. Fluridil is available as a topical medication that is primarily used as a treatment for androgenic alopecia (hormone-induced hair loss). Fluridil is rarely used as a treatment for acne. Fluridil is not available in all countries.

Androgen hormones stimulate the growth and activity of the sebaceous glands and production of sebum, both of which contribute to acne symptoms in some individuals. The elevated levels of androgen hormones during puberty can cause acne in some individuals. Studies of adult females with acne have shown that many of these women have abnormally high levels of androgen hormones in their blood. Fluridil may help improve acne symptoms by reducing the effect of elevated androgen levels.

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Androgen Inhibitors

Spironolactone 25mg Tablets

Androgen Inhibitors are medications that block the affects of androgen (male) hormones. Androgen hormones can contribute to acne symptoms by stimulating the activity of the sebaceous glands and the production of sebum. Androgen Inhibitors can help improve acne symptoms in some individuals.

Below is our ranked list of Androgen Inhibitor medications for use as acne treatments. Our ranking system (Scale: 1 {BAD} to 100 {GOOD}) is based on patient reports, clinical research results and other sources. Click on an Androgen Inhibitor to learn more about that particular medication.

Spironolactone

Spironolactone 25mg Tablets

Spironolactone (Aldactone) is an Androgen Inhibitor medication. These medications block the effect of androgen (male) hormones that contribute to acne symptoms in some individuals. Spironolactone is occasionally used for the treatment of acne, primarily in women.

Spironolactone is not a common treatment for acne, but many patients have reported positive results with this medication. Multiple clinical research studies have also found that Spironolactone can be an effective treatment for acne. Spironolactone is available in oral and topical formulations, but this medication is more commonly administered orally.

Spironolactone inhibits the activity of androgens (male hormones) by blocking the androgen receptor (AR) and inhibiting androgen production. Spironolactone is commonly used off-label to treat a variety of dermatological conditions caused by high androgen levels, such as hair loss, hirsutism and acne. Spironolactone is also used to treat polycystic ovary syndrome.

Androgen hormones stimulate the growth and activity of the sebaceous glands, and production of sebum, which contributes to the pathogenesis of acne. Elevated levels of androgen hormones can trigger acne symptoms during puberty. Studies of adult females with acne have shown that many of these women have abnormally high levels of androgen hormones in their blood. Spironolactone may help improve acne symptoms by reducing the effects of elevated androgen levels. The inhibition of androgen activity can decrease the activity of the sebaceous glands, which can improve acne  symptoms in some patients.

Both oral and topical Spironolactone have been reported to be effective treatments for acne, but the effects (and side effects) are more pronounced with oral Spironolactone. Several studies have indicated that topical Spironolactone can be an effective acne treatment for men and women. Spironolactone is often combined with complementary acne treatments (eg. Antibiotics, Retinoids). For some individuals, Androgen Anhibitors may be a good alternative to Retinoids in the treatment of sebaceous hyperplasia (over-active sebaceous glands).

Spironolactone is generally well reviewed by patients, but the majority of people taking this medication do report mild side effects. Spironolactone works well for many acne sufferers who have acne and oily skin that is caused by elevated levels of androgen hormones. Oral Spironolactone is usually only prescribed to women. Because Spironolactone inhibits the action of androgen hormones, it can have feminizing effects on males. Common side effects of Spironolactone treatment include: menstrual irregularities, ataxia, drowsiness and nausea. Allergic reactions are possible with this medication and may result in rashes, fever and other symptoms. Some studies have suggested that Spironolactone may be carcinogenic, however those results were obtained in rats and used dosages more than 100x higher than the commonly used with humans. Carcinogenicity studies in humans and primates have been inconclusive.

Spironolactone affects the balance of hormones in the body and it is not used in women who are pregnant or may become pregnant. The use of Spironolactone is not recommended for persons taking certain medications used to treat hypertension and depression.

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Cyproterone

Ciproterone 50mg Compresse (Androcur)

Cyproterone Acetate (Androcur) is an Androgen Inhibitor medication. These medications block the effect of androgen (male) hormones that can contribute to acne symptoms in some individuals. Cyproterone is occasionally used for the treatment of acne, primarily in women.

Cyproterone is not a common treatment for acne, but some patients have reported positive results with this medication. Several clinical research studies have also found that Cyproterone can be an effective treatment for acne in women. Cyproterone is primarily available in oral formulations, but topical versions of this medication do exist. Cyproterone is not available in all countries (eg. United States).

Androgen hormones stimulate the growth and activity of the sebaceous glands, and production of sebum, contributing to the pathogenesis of acne. Elevated levels of androgen hormones trigger acne symptoms during puberty. Studies of adult females with acne have shown that many of these women have abnormally high levels of androgen hormones in their blood. Cyproterone may help improve acne symptoms by reducing the effect of elevated androgen levels.

Cyproterone is less commonly used than Spironolactone (a different androgen inhibitor) because Spironolactone tends to have fewer side effects. However, the majority of female acne patients that use either Spironolactone or Cyproterone report significant improvement in their acne symptoms.

Cyproterone has a wider range of potential side-effects than Spironolactone, owing to a broader spectrum of activity on the hormonal system. Because Cyproterone blocks the action of androgen hormones on the body, it can have feminizing effects on males who use this medication. These effects are much more significant when this medication is used orally, as opposed to topical use.

One of the most serious potential side effects of Cyproterone use is liver toxicity. Patients undergoing treatment with Cyproterone are often required to take regular blood tests to monitor changes in liver enzymes. Cyproterone treatment may also have adverse effects on metabolic function and the body’s ability to maintain a proper salt balance. These side effects tend to be dose dependent, and severe side effects occur much more often at high dosage levels. Allergic reactions are also possible with this medication. Common symptoms of an allergic reaction include: Skin rashes, joint pain, fever and anaphylaxis.

Because Cyproterone disrupts normal hormone balance, it is not used in women who are pregnant or expect to become pregnant.

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Dutasteride

Dutasteride (Avodart)

Dutasteride (Avodart) is an Androgen Inhibitor medication. Dutasteride is primarily used as a treatment of male pattern baldness and enlarged prostate. Dutasteride is not routinely used in the treatment of acne.

Dutasteride is generally available in oral formulations, but topical Dutasteride may be better suited for use as an acne treatment. Dutasteride is readily absorbed into the skin, and topically applied Dutasteride is expected to have substantially fewer side effects than oral Dutasteride. Topical Dutasteride solutions may be available in certain regions.

Dutasteride inhibits the synthesis of the powerful androgen (male hormone), DHT. DHT is closely related to Testosterone, but is more potent. Inhibiting the effects of androgen hormones can help improve acne symptoms in some individuals by slowing the growth of the sebaceous glands. In individuals with androgen-induced acne, high levels of androgen hormones cause increased sebaceous gland activity, which leads to elevated sebum production, clogged pores and excessive growth of acne-causing P. acnes bacteria inside follicles.

Dutasteride works by blocking the activity of an enzyme called 5-aplha reductase, which converts testosterone into dihydrotestosterone (DHT). There are two different versions of the 5-alpha reductase enzyme in humans. Finasteride is an Androgen Inhibitor that is closely related to Dutasteride. Dutasteride is a more powerful inhibitor of DHT synthesis than Finasteride because it inhibits both forms of the enzyme, while Finasteride only inhibits one.

Androgen hormones are an essential part of male biology. Because Androgen Inhibitors have significant side effects when used in men, they are usually only used to treat acne in women. However, Dutasteride is one of the few Androgen Inhibitors that is routinely used in men. Two of the most common side effects of Androgen Inhbitor use in men are a reduced sex drive and decreased muscle mass.

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Finasteride

Finasteride Tablets (Propecia)

Finasteride (Propecia) is an Androgen Inhibitor medication. It is commonly used for the treatment of male pattern baldness and enlarged prostate. Finasteride is not routinely used in the treatment of acne.

Finasteride is generally available in oral formulations, but topical Finasteride may be better suited for use as an acne treatment. Finasteride is readily absorbed into the skin, and topically applied Finasteride is expected to have substantially fewer side effects than oral Finasteride. Topical Finasteride solutions are available, although many of them also contain the hair growth stimulator Minoxidil (Rogaine).

Finasteride inhibits the synthesis of the powerful androgen (male hormone), DHT. DHT is closely related to Testosterone, but is more potent. Inhibiting the effects of androgen hormones can help improve acne symptoms in some individuals by slowing the growth of the sebaceous glands. In individuals with androgen-induced acne, high levels of androgen hormones cause increased sebaceous gland activity, which leads to elevated sebum production, clogged pores and excessive growth of acne-causing P. acnes bacteria inside follicles.

Finasteride works by blocking the activity of an enzyme called 5-aplha reductase, which converts testosterone into dihydrotestosterone (DHT). There are two different versions of the 5-alpha reductase enzyme in humans. Dutasteride is an Androgen Inhibitor that is closely related to Finasteride. Dutasteride is a more powerful inhibitor of DHT synthesis than Finasteride because it inhibits both forms of the enzyme, while Finasteride only inhibits one.

Androgen hormones are an essential part of male biology. Because Androgen Inhibitors have significant side effects when used in men, they are usually only used to treat acne in women. However, Finasteride is one of the few Androgen Inhibitors that is routinely used in men. Two of the most common side effects of Androgen Inhbitor use in men are a reduced sex drive and decreased muscle mass.

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Flutamide

Flutamide 250mg Tablets (Fugerel)

Flutamide (Fugerel) is an Androgen Inhibitor medication that blocks the activity of androgens (male hormones). Flutamide is rarely used for the treatment of acne.

Flutamide is a synthetic non-steroidal anti-androgen (NSAA). It is primarily used for the treatment of prostate cancer, hirsutism (excessive body hair growth) and as part of the hormone replacement regimen for transgender women. Flutamide blocks the ability of a receptor to bind androgen hormones, such as testosterone and dihydrotestosterone (DHT). Flutamide has largely been replaced by a closely-related medication, Bicalutamide, which tends to be more effective and have fewer side effects.

Androgen hormones can contribute to acne symptoms by stimulating the sebaceous glands to grow and produce more sebum. The increased sebaceous gland activity can lead to clogged pores and excessive growth of acne-causing P. acnes bacteria inside follicles. Androgen Inhibitors like Flutamide can improve acne symptoms by decreasing the activity of sebaceous glands, which leads to a decrease in sebum production.

Androgen hormones are an essential part of male biology. Because androgen inhibitors have significant side effects when used in men, they are usually only used to treat acne in women. The use of Androgen Inhibitors can improve acne symptoms for some female patients, but not all. Testosterone is the best known androgen.

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Bicalutamide

Bicalutamide (Casodex) Tablets

Bicalutamide (Casodex) is an Androgen Inhibitor medication that blocks the activity of androgens (male hormones). Bicalutamide is rarely used for the treatment of acne.

Bicalutamide is a synthetic non-steroidal anti-androgen (NSAA). It is most frequently used for the treatment of prostate cancer, hirsutism (excessive body hair growth) and as part of the hormone replacement regimen for transgender women. Bicalutamide blocks the ability of a receptor to bind androgen hormones, such as testosterone and dihydrotestosterone (DHT).

Androgen hormones can contribute to acne symptoms by stimulating the sebaceous glands to grow and produce more sebum. The increased sebaceous gland activity can lead to clogged pores and excessive growth of acne-causing P. acnes bacteria inside follicles. Androgen Inhibitors can improve acne symptoms by decreasing the activity of sebaceous glands, which leads to a decrease in sebum production.

Androgen hormones are an essential part of male biology. Because androgen inhibitors have significant side effects when used in men, they are usually only used to treat acne in women. The use of Androgen Inhibitors can improve acne symptoms for some female patients, but not all. Testosterone is the best known androgen.

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