Isotretinoin {Topical}

Isotretinoin Gel (Isotrex)

Topical Isotretinoin (Isotrex) is a retinoid medication that is used as a topical treatment for certain types of skin disorders, including acne. Topical retinoids are popular acne treatments that can help improve symptoms for many individuals. Topical Isotretinoin is an older-generation topical retinoid that has largely been replaced by newer topical retinoids (eg. Adapalene, Tazarotene). Topical Isotretinoin contains the same active ingredient as the more well-known oral form of this medication – Accutane.

Retinoids are derivatives of Vitamin A. Retinoids can help improve acne symptoms in several ways. Retinoids decrease the activity of the sebaceous glands, which decreases the production of sebum. The decrease in sebum in eliminates decreases the amount of nutrients that are available for acne-causing bacteria that live deep within hair follicles. Retinoids can also affect the growth and differentiation of skin cells, which can help reduce the formation of clogged pores (comedomes). Retinoids also have anti-inflammatory affects which may help improve acne symptoms.

Isotretinoin works by entering target cells and binding to to specific receptors called Retinoic Acid Receptors that are in the nucleus of cells. Once the retinoid binds to these receptors it changes how the genes of that cell are expressed. These changes in gene expression are what give retinoids their anti-acne properties.

Topical Isotretinoin is becoming less popular for the treatment of acne. Topical Isotretinoin tends to be less effective and have more significant side effects than alternative topical retinoids (eg. Adapalene, Tazarotene, Tretinoin).

Topical Isotretinoin is frequently used in combination with complementary anti-acne medications, such as topical or oral antibiotics. These combinations are often more effective at improving acne symptoms and improve the overall effectiveness of treatment. Topical Isotretinoin and other topical retinoids tend to be more effective for the treatment of mild acne (Acne Types: 1-2) and less effective for moderate and severe forms of the disease (Acne Types: 3-4). Some available medications combine Isotretinoin with another antibacterial compound, such as Erythromycin (eg. Isotrexin).

The most common side effect of treatment of Topical Isotretinoin use is dryness of the skin. Isotretinoin treatment decreases the production of sebum, and sebum is essential for moisturizing and protecting the skin. Isotretinoin tends to have more significant side effects than newer topical retinoids, such as Adapalene and Tazarotene.

The most serious potential side effect of Isotretinoin is a risk of birth defects. All retinoids are teratogens (compounds that can cause birth defects). However, several studies have indicated that there is minimal risk to the fetus from the topical use of retinoids, including Isotretinoin. Nonetheless, the use of any type of retinoid is generally avoided in all women who are pregnant or may become pregnant during treatment.

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Tazarotene

Tazarotene Cream (Tazorac)

Tazarotene (Tazorac) is a synthetic retinoid that is used as a topical treatment for certain types of skin disorders, including acne. Topical retinoids are popular acne treatments that can help improve symptoms for many individuals. Tazarotene is a newer-generation topical retinoid that has a similar efficacy profile as older topical retinoids (eg. Tretinoin) but tends to have milder side effects. Adapalene is another newer-generation retinoid that is more popular than Tazarotene for the treatment of acne because Adapalene tends to be less expensive than Tazarotene and Adapalene is now available as an Over-The-Counter (OTC) medication.

Retinoids are derivatives of Vitamin A. Retinoids can help improve acne symptoms in several ways. Retinoids decrease the activity of the sebaceous glands, which decreases the production of sebum. The decrease in sebum in eliminates decreases the amount of nutrients that are available for acne-causing bacteria that live deep within hair follicles. Retinoids can also affect the growth and differentiation of skin cells, which can help reduce the formation of clogged pores (comedomes). Retinoids also have anti-inflammatory affects which may help improve acne symptoms.

Tazarotene works by entering target cells and binding to to specific receptors called Retinoic Acid Receptors that are in the nucleus of cells. Once the retinoid binds to these receptors it changes how the genes of that cell are expressed. These changes in gene expression are what give retinoids their anti-acne properties.

Tazarotene is a moderately popular topical retinoid for the treatment of acne. Research studies have indicated that is has a similar effectiveness as Tretinoin and Adapalene. It also tends to be well tolerated by patients, with minimal side effects. Tazarotene can be a valuable treatment for individuals with any type of acne (Acne Types: 1-4). Many clinical research studies have shown that regular use of Tazarotene can improve acne symptoms. But clinical research and patient reports demonstrate that complete resolution of acne symptoms is rare when Tazarotene is used alone.

Tazarotene is frequently used in combination with complementary anti-acne medications, such as topical or oral antibiotics. These combinations can accelerate improvements in acne symptoms and improve the overall effectiveness of treatment. Tazarotene and other topical retinoids tend to be more effective for the treatment of mild acne (Acne Types: 1-2) and less effective for moderate and severe forms of the disease (Acne Types: 3-4).

The most common side effect of treatment with Tazarotene is dryness of the skin. Tazarotene treatment decreases the production of sebum, and sebum is essential for moisturizing and protecting the skin. Tazarotene tends to have fewer and milder side effects than older topical retinoids, such as Tretinoin and Isotretinoin.

The most serious potential side effect of Tazarotene is a risk of birth defects. All retinoids are teratogens (compounds that can cause birth defects). However, several studies have indicated that there is minimal risk to the fetus from the topical use of retinoids, including Tazarotene. Nonetheless, the use of any type of retinoid is generally avoided in all women who are pregnant or may become pregnant during treatment.

Tazarotene tends to be more expensive than other available topical retinoids.

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Tretinoin

Tretinoin Cream (Retin-A)

Tretinoin (Retin-A) is a topical retinoid that is used as a treatment for active acne symptoms and minor acne scarring. Tretinoin was once the most commonly used topical retinoid for the treatment of acne, but newer retinoid medications (eg. Adapalene, Tazarotene) are now becoming more popular.

Retinoids are derivatives of Vitamin A. Retinoids can help improve acne symptoms in several ways. Retinoids decrease the activity of the sebaceous glands, which decreases the production of sebum. The decrease in sebum in eliminates decreases the amount of nutrients that are available for acne-causing bacteria that live deep within hair follicles. Retinoids can also affect the growth and differentiation of skin cells, which can help reduce the formation of clogged pores (comedomes). Retinoids also have anti-inflammatory affects which may help improve acne symptoms.

Tretinoin works by entering target cells and binding to to specific receptors called Retinoic Acid Receptors that are in the nucleus of cells. Once the retinoid binds to these receptors it changes how the genes of that cell are expressed. These changes in gene expression are what give retinoids their anti-acne properties.

Tretinoin can be a valuable treatment for individuals with any type of acne (Acne Types: 1-4). Many clinical research studies have shown that regular use of Tretinoin can improve acne symptoms. But clinical research and patient reports demonstrate that complete resolution of acne symptoms is rare when Tretinoin is used alone.

Tretinoin is frequently combined with complementary acne treatments (eg. Antibiotics, Androgen Inhibitors, Light & Laser therapies, etc). Tretinoin and other topical retinoids tend to be more effective for the treatment of mild acne (Acne Types: 1-2) and less effective for moderate and severe forms of the disease (Acne Types: 3-4).

There are topical medications available that combine Tretinoin with a second antibacterial agent, such as the antibiotic Clindamycin (Treclin). These combinations can be synergistic, further decreasing bacterial growth and leading to greater improvements in acne symptoms. Tretinoin may also be combined with Over-The-Counter (OTC) topical treatments, like Benzoyl Peroxide, although this particular combination can be lead to excessive dryness and irritation of the skin.

The most common side effect of Tretinoin treatment is dryness of the skin. Tretinoin treatment decreases the production of sebum, and sebum is essential for moisturizing and protecting the skin. Tretinoin tends to have more significant side effects (eg. Dry skin) than newer topical retinoids, such as Adapalene.

The most serious potential side effect of Tretinoin is a risk of birth defects. All retinoids are teratogens (compounds that can cause birth defects). However, several studies have indicated that there is minimal risk to the fetus from the topical use of retinoids, including Tretinoin. Nonetheless, the use of any type of retinoid is generally avoided in all women who are pregnant or may become pregnant during treatment.

 

 

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Adapalene

Adapalene and Benzoyl Peroxide Gel Pump (Epiduo)

Adapalene (Differin) is a topical retinoid that is used primarily for the treatment of acne. Adapalene is one of the most commonly used topical retinoids. Adapalene is a synthetic, third-generation retinoid that has better efficacy and safety profiles than older topical retinoids (eg. Isotretinoin, Tretinoin). This medication is now available as an Over-The-Counter (OTC) product in some regions.

Retinoids are derivatives of Vitamin A. Retinoids can help improve acne symptoms in several ways. Retinoids decrease the activity of the sebaceous glands, which decreases the production of sebum. The decrease in sebum in eliminates decreases the amount of nutrients that are available for for acne-causing bacteria, such as P. acnes. Retinoids can also affect the growth and differentiation of skin cells, which can help reduce the formation of clogged pores (comedomes). Retinoids also have anti-inflammatory affects which may help improve acne symptoms.

Multiple clinical research studies indicate that Adapalene has similarly effective for treating acne as another common topical retinoid, Tretinoin, but has milder side effects. Adapalene works by entering target cells and binding to to specific receptors called Retinoic Acid Receptors that are in the nucleus of cells. Once the retinoid binds to these receptors it changes how the genes of that cell are expressed. These changes in gene expression are what give retinoids their anti-acne properties.

Adapalene can be a valuable treatment for individuals with any type of acne (Acne Types: 1-4). Adapalene can improve acne symptoms for many patients, but complete resolution of acne symptoms is rare when Adapalene is used alone. Adapalene is frequently combined with complementary acne treatments (eg. Antibiotics, Androgen Inhibitors, Light & Laser therapies, etc). Adapalene and other topical retinoids tend to be more effective for the treatment of mild acne and less effective for moderate and severe forms of the disease.

There are many topical medications available that combine Adapalene with a second antibacterial agent. Adapalene is widely available in combination treatments with Benzoyl Peroxide (Epiduo), Clindamycin (Lacne) and Azithromycin (ATM-A).

The most common side effect of Adapalene treatment is dryness of the skin. Adapalene treatment decreases the production of sebum, and sebum is essential for moisturizing and protecting the skin. Most retinoid treatments cause dry skin, but Adapalene tends to have milder side effects than other topical retinoids, such as Tretinoin and Isotretinoin. The most serious potential side effect of Adapalene is a risk of birth defects. All retinoids are teratogens (compounds that can cause birth defects). However, several studies have indicated that their is minimal risk to the fetus from the topical use of retinoids, including Adapalene. Nonetheless, the use of any type of retinoid is generally avoided in all women who are pregnant or may become pregnant during treatment.

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Isotretinoin {Oral}

Isotretinoin (Roaccutane) 20mg Capsules

Isotretinoin (Accutane) is a type of acne treatment called a Retinoid. Isotretinoin is available as an oral treatment (Accutane) and as a topical treatment (Isotrex). Oral Isotretinoin is one of the most effective treatments for moderate to severe acne. Unfortunately, oral isotretinoin also frequently has significant side effects.

Isotretinoin works by decreasing the size and activity of sebaceous glands, thus reducing the production of sebum. The reduced production of sebum limits the growth of acne-causing bacteria within the follicle. Isotretinoin also prevents the formation of the pore-clogging plugs that create blackheads and whiteheads.

Oral Isotretinoin has several side effects, which range from mild to severe. Isotretinoin can cause the skin to become very dry and irritated because sebum is necessary to lubricate and protect the skin. The effects of Oral Isotretinoin are semi-permanent, and some patients experience side effects even after they discontinue use of isotretinoin.

Isotretinoin is a powerful teratogen, and  the use of Oral Isotretinoin by pregnant women causes severe birth defects. Because of the risk of this side effect, the use of oral isotretinoin is tightly controlled in many countries. Women who are pregnant or may become pregnant should never use isotretinoin.

Oral Isotretinoin has also been associated with an increased risk of depression and suicidal thoughts. However, this relationship is controversial and is not accepted by all experts. Isotretinoin is used primarily for individuals with severe acne, so it is unclear whether the increased risk of depression is caused by the Isotretinoin itself or from the experience of having severe acne symptoms.

Topical Isotretinoin (Isotrex) has a much lower risk of side effects, but it is rarely used to treat acne because newer topical retinoids (eg. Adapalene, Tretinoin) tend to be more effective and produce fewer side effects. Topical Isotretinoin is generally substantially less effective than Oral Isotretinoin for the treatment of moderate to severe acne symptoms (Acne Types: 3-4).

Isotretinoin Images