Silver Sulfadiazine (Silvadene) is an antibiotic in the Sulfonamide family. Silver Sulfadiazine also contains ionic silver, which has antibacterial properties. Silver Sulfadiazine is used to treat certain types of bacterial skin infections, and is commonly used to prevent secondary infections in burn patients.
Silver Sulfadiazine is occasionally used as a topical treatment for acne. Although there is minimal clinical research on the efficacy of Silver Sulfadiazine for the treatment of acne, some patients have reported that this medication helped improve their acne symptoms.
Antibiotic susceptibility testing indicates that the acne-causing P. acnes bacterium tends to be moderately susceptible to Sulfonamide antibiotics, including Sulfadiazine. Silver Sulfadiazine is likely to be most effective when combined with complementary systemic or topical acne treatments. Silver Sulfadiazine is a medication that deserves further investigation into its utility as an acne treatment.